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As the sensitization of the primary nociceptive neuron at the peripheral and spinal levels also plays a crucial role in the generation and maintenance of neuropathic pain, and most of the nociceptive mediators (inflammatory cytokines, protons, prostaglandins, ATP, etc.) that activate nociceptors are shared by both inflammatory and neuropathic pain [45,47,48,49], one could assume that cortistatin would be able to tune down directly the neural activity through these same mechanisms

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6.4.1 Rheumatoid arthritis Rheumatoid arthritis is an autoimmune condition characterized by synovial growth and cellular penetration