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Ldicke F, Ansari SM, Lama N, Blanc N, Bosilkovska M, Donelli A, Picavet P, Baker G, Haziza C, Peitsch M, Weitkunat R (2019) Effects of switching to a heat-not-burn tobacco product on biologically relevant biomarkers to assess a candidate modified risk tobacco product: a randomized trial

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People grow a tolerance to this drug pretty quickly and in order to get a better fix, people try to up their intake, this result in overdose and death

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