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Safety of higher doses of melatonin in adults: a systematic review and meta-analysis

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SAM is a methyl group donor for numerous methylation reactions in the brain, including those involved in the metabolism of neurotransmitters whose deficiency has been related to depression (102)

This may affect stability and provides additional L-arginine at the site of activity, which could be relevant given BPC-157s NO-system mechanism

In this blend they are already combined, and the pairing has a mechanistic rationale: NAD+ supplies the coenzyme, while 5-Amino-1MQ blocks the NNMT enzyme that would otherwise drain NAD+ precursors [4]