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Nature 384 , 327333 (1996)

Without orthogonal or in vivo validation, such effects may mislead interpretation, especially in in vitro models evaluating membrane-related functions ( in vitro studies, and rigorously designed in vivo studies remain limited, future research should aim to reduce potential PAINS-related artifacts and enhance translational relevance by integrating pharmacokinetic and pharmacodynamic data, systematically evaluating membrane-related interference, and rigorously validating target specificity

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Five ( n = 71.4%) were licensed clinical psychologists and two ( n = 28.6%) were clinical psychology students in their final year and received clinical supervision