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Free heme is dangerous in excessive quantities (15) which is why it is quickly removed from tissues through hydrolyzation by microsomal heme-oxygenase, specifically at the -methane bridge

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Compound 18 significantly reduced the levels of TNF-, IL-6, COX-2, and iNOS in LPS-stimulated BV-2 microglial cells

Consistent with these findings, Chinese cohort studies have shown reduced indirect BL levels in PD patients ( p = 0.015), with the most significant reductions observed in early-stage disease ( p = 0.013

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