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To begin with, PD patients are more prone to developing Vit B12 deficiency which may be linked to several factors such as typical low-protein diet in LDopa treated PD, delayed gastric emptying due to autonomic dysfunction, bacterial overgrowth along with helicobacter pylori (HP) infection aggravated by the occurrence of constipation (Fasano et al

Excretion and clearance 7

Muscle wasting in sarcopenia populations, is associated with a shift from muscle protein synthesis to muscle protein degradation facilitated by the ubiquitinproteasome system (UPS) [48]

Previous evidence demonstrated that cortistatin is produced by primary sensitive neurons that innervated laminae IIII of the spinal cord dorsal horn and by GABAergic interneurons localized in laminae IVV and that exert inhibitory actions on the sensitization of spinal secondary nociceptors [22]