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Liang et al., 2023a)

This multi-pathway approach aligns with research published in the International Journal of Molecular Sciences showing GHK-Cu stimulates collagen, elastin, and glycosaminoglycan synthesis simultaneously

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One possible explanation for such a response is that inhibition of mTORC1 and activation of GCN2 collectively suppresses global translation to conserve nutrients, while selective translation of mRNA such as ATF4 (mediated by increased p-eIF2) activates the expression of AARE genes to mitigate cellular stress

[DOI] [PubMed] [Google Scholar] 16.Targovnik HM, Citterio CE, Rivolta CM