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Furthermore, target individual cytokines (anti-IL-1 glucocorticoids, anti-IL-6 simvastatin/haritaki) and small molecules that modulate upstream regulators such as p53 (nutlin-3a) or inhibit LINE-1-driven inflammatory signaling (nucleoside reverse transcriptase inhibitors like lamivudine) also function as SASP inhibitors

The nausea from oral semaglutide tends to be more frequent than from the injectable form because of higher local concentrations in the GI tract

Nakamura A, et al

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