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Recent evidence suggests that MCC is more likely to originate from dermal fibroblasts, epidermal keratinocytes, or immature totipotent stem cells that undergo neuroendocrine differentiation during the process of malignant transformation [57, 58]

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10.1046/j.0007-0963.2001.04556.x 112 KarnD.KcS.AmatyaA.RazouriaE

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Research indicates that alterations in the composition of gut microbiota may compromise the mucus layer and diminish its ability to protect against hypoxia 71