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Classic identification methods include phage lysis testing, oxidative metabolism assays, and agglutination with monospecific antisera (37)

Heffernan MA, Thorburn AW, Fam B, et al

Sorafenib induces ferroptosis by targeting the cystine/glutamate anti-transport system Xc- [154,155,156,157], an effect that impinges on cystine uptake, thereby preventing subsequent synthesis of glutathione (GSH), the major intracellular antioxidant, preventing GPX4 activation [158, 159], and can trigger ER stress and ferroptosis

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Combination of sorafenib and arsenic trioxide exerts synergistic anti-leukemia effects in sorafenib-resistant FLT3-ITD-harboring AML cells