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FOXO4-DRI counteracts senescence and features of frailty in fast aging Xpd TTD/TTD mice TTD/TTD We next wondered whether FOXO4-DRI could influence the healthspan of mice in which senescence and the concomitant loss of tissue homeostasis were not actively induced, but were allowed to develop spontaneously as a consequence of aging

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To counteract the consequences of L-NAME and/or L-arginine administration with the disturbed hemostasis, we administered the stable gastric pentadecapeptide BPC 157 [1,2,1026] not only due to its special effect on hemostasis [1,2], but also owing to a particular beneficial combining [1,2,1014], wound healing capacity [1,2,1017] and particular interaction with NO-system [14,15,1826]