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This binding depends on the intact N-terminal hexapeptide sequencemechanical shear stress from shaking or direct powder impact can break peptide bonds in that sequence, reducing receptor binding affinity by 1540%

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[DOI] [PubMed] [Google Scholar] Mukhopadhyay P, Horvth B, Rajesh M, Varga ZV, Gariani K, Ryu D, et al

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Elife 7: e42166 van Zundert GC, Bonvin AM (2015) DisVis: quantifying and visualizing accessible interaction space of distancerestrained biomolecular complexes