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The progressive load design was deliberately chosen to push participants to their maximal effort, ensuring that the effects of supplementation on endurance performance could be fully assessed under intense conditions

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Moreover, GMD is also efficient in other types of senescence inductions such as genotoxic stresses, irradiation, and replicative exhaustion

Members of the Smad family, specifically Smad5, which are signal transduction proteins coupled to activated TGF- family receptors, play a role in the regulation of cytosolic pH in pancreatic -cells

Its unique properties make it a valuable tool in scientific research on obesity and metabolism regulation