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Supplementary material The Supplementary Material for this article can be found online at: References 1 AdachiS.KawamotoT.OtsukaM.TodorokiT.FukaoK

The people who are at the highest risk of B12 insufficiency or deficiency are older adults, those with atrophic gastritis, gastrointestinal disorders, pernicious anemia, those who have had gastrointestinal surgery, vegans, and vegetarians

They can complement each other by promoting collagen production and skin rejuvenation

Ongoing investigations assess 5-Amino-1MQs potential applications in obesity-related models, metabolic disease research, insulin sensitivity pathways, and age-associated cellular function studies

Others apply only in the morning to avoid any potential product transfer during sleep