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The standard schedule is a starting point, not a strict rule The 2024 NICE guideline NG239 on B12 deficiency in over 16s makes an important point: the optimal route, dose and frequency of B12 replacement have never been firmly established, and have often followed custom and historical practice

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Within complex I, RIPK1 is ubiquitinated by cIAP1/2, promoting cell survival

Unlike other nutrients, B12 requires the presence of a protein called intrinsic factor (IF) to be absorbed