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In addition, in a two-stage, double-blind, randomized, placebo-controlled trial, lixisenatide treatment in early PD participants resulted in slower progression of movement disorders at 12 months than placebo treatment, but the treatment also caused gastrointestinal side effects [168]

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FOXO4 should be capable of continuing to play a vital role in the transcription of genes for antioxidant enzymes, such as manganese superoxide dismutase (MnSOD), catalase (CAT), and glutathione peroxidase (GPX)

LombardiRAiraghiLTargherGServiddioGMaffiGMantovaniAet al