* Correspondence: Guadalupe Estrada-Gutierrez, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
Non-toxic or less hazardous chemicals should replace toxic compounds to minimize negative impacts on the environment and the public, according to government laws
Taurine is a sulfur-containing free amino acid present in the body with concentration ranges between 5 and 20 m/g, particularly in excitable tissues such as muscles, but it can also be obtained from external sources like meat and sea-food (Huxtable, 1992, 2000
Interestingly, only one compound, juglone, was able to completely inhibit ChaC1 activity at this concentration (Figure 5)
However, excessive activation of PARP1 results in the excessive accumulation of poly(ADP-ribose) (PAR) molecules