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However, human clinical trials remain scarce
doi: 10.1016/j.celrep.2021.108771 Summary Keywords childhood cancer, neuroblastoma, combination therapy, oxidative stress, DPI, MitoQ, metabolism Citation Epp S, Egan D, Poon E, Abdul Aziz AA, Wynne K, Chesler L, Halasz M and Kolch W (2025) Oxphos targeting of MYCN -amplified neuroblastoma
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H 2 O 2 can oxidize proteins and lipids, but also act as a signaling molecule modulating various cellular processes linked to oncogenesis ( 2 O 2 precisely to avoid excessive oxidative damage, while enabling the pro-tumorigenic effects of H 2 O 2 signaling
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