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Metabolic pathway enrichment analysis revealed that CAR T cell products of LTR have significantly increased pools of TCA metabolites, nucleotide biosynthesis intermediates, sphingolipid metabolism, and intermediates in central energy metabolism, as well as significantly decreased nucleotide catabolic and tRNA metabolism intermediates, which is critical for T cell activation 10 , compared to those of STR (Fig

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Quick Answer: Insomnia is not listed as a common side effect of tirzepatide in FDA prescribing information or major clinical trials, though some patients report sleep disturbances that may be indirectly related to gastrointestinal symptoms or metabolic changes