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It mimics two natural gut hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)

The 12-week schedule keeps that dose constant while frequency falls: daily in weeks 14, five times weekly in weeks 58, and two or three times weekly in weeks 912

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Among them, the monkey PD model is currently the gold standard for preclinical testing of therapies (Bezard and Przedborski, 2001)