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doi:10.3390/ijms22168677

The homeostasis of iron is also maintained through the regulation of iron absorption, as 1 to 2 mg of iron is lost daily due to skin desquamation, mucous cell sloughing, and blood loss, and the human body has no mechanism to actively remove iron [17]

Naunyn Schmiedebergs Arch Pharmacol 396:877900

They result from a combination of factors such as decreased collagen and elastin production, loss of hydration, and cumulative damage from environmental factors like UV exposure