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It is the reference molecule for studying redox balance and the oxidative protection of tissues

PCR products were directly sequenced using Sanger method to identify mutation

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The WT or mutant plasmids were then transfected into HNF4-negative SNU449 cells together with the control pRL-TK (Renilla Luciferase, Promega), and the control pcDNA3 vector or pcDNA3-HNF4 construct

Functional studies have further confirmed the criticality of CLR synergy: mice with double deletion of Dectin-1 and Dectin-2, or triple deletion of Dectin-1, Dectin-2, and Mincle, exhibit significantly increased susceptibility to systemic C