SAM acts as a key methyl donor for most methylation modifications, including the methylation of DNA, RNA, lipids and histones, and also participates in polyamine biosynthesis, which has a function in multiple cellular processes including regulation of chromatin structure, transcription and translation, DNA stabilization, cell growth and proliferation [50]
2016;5:e47
Glutathione acts as a direct antioxidant
Potential utility of melatonin in preeclampsia, intrauterine fetal growth retardation, and perinatal asphyxia
So if you're pregnant, you can't get Glutathione. Still, anyone with underlying conditions like asthma, kidney disease, or sensitivities to sulfur-containing compounds should consult a healthcare provider before use