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IGF1R was a predicted target of miR-497, and the authors showed that IGF1R negatively correlated with miR-497 and correlated positively with AFAP-AS1 expression in osteosarcoma tissues

These treatments mitigate the adverse effects of cellular senescence, such as inflammation and organ decline over time

Mahan M, Flor R, Purt B

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doi: 10.1016/j.copbio.2008.06.004