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BPC 157 (Band Bn, 10 g/kg and 10 ng/kg, respectively), L-NAME (N, 5 mg/kg), and L-arginine (A, 100 mg/kg) were administered alone or combined while controls received equivolume saline (5 mL/kg) intraperitoneally

Future Direction and Call to Action The current evidence gap presents an opportunity for orthopaedic investigators to establish high-quality prospective registries evaluating peptide exposure in real-world musculoskeletal populations

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Consider that efficacy varies from 90% for treatment within 24 hours, reducing to 10% when treatment is delayed 3 days