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We moved away from IV because intracellular NAD+ levels, which is where the benefit actually happens, do not reliably increase with IV administration

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Additionally, Shishido et al (80) demonstrated that the adhesion of OC cells to the peritoneal mesothelium is facilitated by the interaction between the OCSC markers CD44 and integrin-1, which are recognized by hyaluronic acid receptors on the mesothelial cell membrane (80)

The modulation of iron and lipid metabolic pathways to induce ferroptosis may provide a synergistic effect when combined with immunotherapeutic approaches [86]