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We propose that cigarette smoking impairs immunosuppressive function of Tregs by reducing the number of suppressive Tregs or increasing the prevalence of non-suppressive Tregs, leading to an enhanced autoimmune component in COPD pathogenesis, while increased Treg numbers may occur in some smokers under circumstances, leading to worsened respiratory infections

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Apart from physical dependence on nicotine, smokers find it hard to give up cigarettes smoking because it is a habit associated with their daily routine

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Many of the detected organisms are capable of causing pneumonia, bacteremias, foodborne illnesses, meningitis, endocarditis, and urinary tract infections [28]