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PMID: 21700179
Conditions that can cause cobalamin deficiency include: Inflammatory bowel disease (IBD) Exocrine pancreatic insufficiency (EPI) Pancreatic cancer Chronic enteropathy Alimentary lymphoma Small intestinal dysbiosis Inherited selective cobalamin malabsorption Inherited selective cobalamin malabsorption, which is known as Imerslund-Grsbeck syndrome (IGS) in humans, makes a dog genetically predisposed to have difficulty absorbing cobalamin
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Funding We acknowledge financial support from the National Key R&D Program of China (2022YFA0912800), National Excellent Young Scientists Fund (00308054 A1045), National Natural Science Foundation of China (22178233), Talents Program of Sichuan Province, Double First-Class University Plan of Sichuan University, State Key Laboratory of Polymer Materials Engineering (sklpme 20200301), Tianfu Emei Program of Sichuan Province (2022-EC02-00073-CG), Postdoctoral Special Funding of Sichuan Province (TB2022063), Postdoctoral Funding of Sichuan University (2022SCU12099), Ministry of Education Key Laboratory of Leather Chemistry and Engineering, and National Engineering Research Center of Clean Technology in Leather Industry
Together, these data demonstrate that ablation of GSH synthesis in mice results not only in reduced expression of lipogenic enzymes but also lower levels of their corresponding lipid species
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