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Updated analyses from the HEALEY ALS Platform Trial suggest a notable reduction in the risk of death in reviewed populations, alongside a favorable safety profile across more than 1,000 patient-years of exposure

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10.1371/journal.pone.0157602 330 MullerM.LeavittB

Within the gastrointestinal tract, gut bacteria facilitate the conversion of choline and carnitine into trimethylamine (TMA), which is further metabolized in the liver to produce TMAO (Wang et al., 2011)

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