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Pulled from the verification packet included with each shipment

These treatments mainly work by boosting dopamine signaling in the brain, or by altering the activity of other neurotransmitters that help control movement

Specifically, NCX4040 treatment led to increased reactive oxygen species (ROS), lipid peroxidation, and activation of ferroptosis-related genes such as CHAC1 , GPX4 , and NOX4

This effect remained significant in a multivariate logistic regression model

However, the prevailing biological hypothesis for konzo development is that famine-stricken populations rely on diets that are deficient in the key sulfur amino acids methionine and cysteine, likely decreasing their ability to fully detoxify cyanide 10,11