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Modified DPP-4 can not only mask the enzymatic hydrolysis site of DPP-4 but also bind closely with albumin to reduce renal excretion and prolong the half-life

doi:10.2147/JPR.S132769 3 Chang, Douglas, Zlomislic, Vinko

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It works by activating downstream biological processes such as: Receptor activation Growth factor upregulation Angiogenesis Cellular signaling cascades These processes continue for weeks after the peptide itself has been cleared from circulation