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Role of astroglia in Downs syndrome revealed by patient-derived human-induced pluripotent stem cells

Sakai D, Nakamura Y, Nakai T, Mishima T, Kato S, Grad S, Alini M, Risbud MV, Chan D, Cheah KS, Yamamura K, Masuda K, Okano H, Ando K, Mochida J: Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc

Principal component analysis (PCA) was run on the top 3,000 variable genes and initial clustering (resolution = 0.1, top 30 PCs) separated neurons from glia using known markers

Antibody-dependent enhancement of virus infection and disease

So far, there is an absence of viable cure or way to halt its development