V., Andreeva, L., Shevchenko, K., & Myasoedov, N
As previously described (Strbe et al., 2021), intestinal tissue damage was analyzed using a histologic scoring scale adapted from Chui and coworkers (Chui et al., 1970) on a scale of 05 (normal to severe) in three categories (mucosal injury, inflammation, and hyperemia/hemorrhage) for a total score of 015, as described by Lane and coworkers (Lane et al., 1997)
For example, IRE delivers high-voltage electric pulses to disrupt cellular membrane integrity, inducing immunogenic cell death (ICD) through damage-associated molecular pattern (DAMP) release and loss of intracellular homeostasis ( + T-cell infiltration ( + T-cell quality/quantity and extend survival ( + T-cell conversion to antitumor Th1/Th17 subsets in MHC-I-low PDAC, where subsequent PD-L1 blockade activates compensatory cDC2-CD4 + T-cell axes ( 3.2 Hepatocellular carcinoma Clinical studies have established IRE as a safe and effective hepatocellular carcinoma (HCC) ablation modality, with ongoing optimization of efficacy assessment methods and device engineering complementing robust evidence of its antitumor effects
Non-clinical only: Not intended for diagnostic, therapeutic, or clinical use
They are documented, real-world problems that affect real people every single day
