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This strategy was integrated with dynamic modeling and a molecular immunologic approach to demonstrate that p28 also binds stably and with high affinity to the DBD of p63 and p73 but, unlike p53, 6,7 does not uniformly increase the intracellular level of either by inhibiting the binding of HECT or RING E3 ubiquitin ligases

Accuracy (% recovery) Three different concentration levels (80%, 100% and 120%) of this parameter were examined through replicate analysis ( n = 3)