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Pharmacokinetic scaling across species rodent to larger animal to human extrapolation has not been rigorously published

For further information regarding WADAs approach to the routes of administration of glucocorticoids and washout periods, please refer to the Summary of Major Modifications and Explanatory Note

Tirzepatide activates both GLP-1 and GIP receptors, resulting in slightly higher constipation rates (2527% in trials) compared to semaglutide (1520%)

T., and Kung, H

The shift between these two states are dependent on the type, strength and duration of activation and thus impacts and reflects an individuals metabolic health