Carcinogens in tobacco smoke initiate genetic mutations in lung cells, leading to the uncontrolled growth of cancerous cells
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In aircraft with cabins in which the cockpit is not physically separated from the passenger cabin, such as smaller propeller aircraft for short-haul flights, smoking is still prohibited
The G allele of a second variant in the region, rs7096169 (intronic to BORCS7 and only in weak LD with rs12780116, r 2 = 0.18 in 1000G Europeans) increases smoking initiation and reduces expression of BORCS7 and AS3MT in eight brain tissues (including dorsolateral prefrontal cortex in the Brain xQTL and was the top BORCS7 eSNP in GTEx in the Cerebellar Hemisphere, Cerebellum, and Spinal cord cervical-C1)