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These authors also discussed the possibility that vitamin supplementation can mask the expected fall in Hcy levels in the presence of creatine supplementation

Glutamate is a component of GSH and may play a role in the formation of GSH 27

In more severe cases, clinically significant interstitial nephropathy develops, mediated by deposition of MSU crystals in the physiologic pH milieu of the renal medullary interstitium (a condition termed gouty nephropathy, which impairs renal function)

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