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The original patent documentation describes this mechanism in detail, noting that the peptide stimulates lipolysis and inhibits lipogenesis via beta-adrenergic signalling at concentrations far below those needed to activate growth-promoting pathways

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By comparing the gene expression profiles of the skin microbiota in acne patients with the profiles from healthy individuals, the vitamin B 12 biosynthesis pathway in the skin bacterium Propionibacterium acnes turned out to be significantly down-regulated in acne patients

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