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The classic mechanism of acetaminophen hepatotoxicity is that its reactive metabolite, N-acetyl-p-benzoquinoneimine (NAPQI), depletes GSH and then covalently binds to proteins

Glutathione Assay (Colorimetric) (4 Citations) Reduced glutathione (L--glutamyl-L-cysteinylglycine), a tripeptide, serves as a key antioxidant in animal, plant, fungi and bacteria by providing free thiol

Since glutathione is a naturally occurring antioxidant in your body, supplementation simply helps restore levels that decline due to age, UV exposure, and environmental stressors

Also, they evaluated the immunohistochemical expression of GSH on pre-treatment biopsies, finding a stronger expression of GSH in NAFL than NASH