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Glutathione is a critical antioxidant that protects cells from oxidative stress by neutralizing free radicals and reactive oxygen species (ROS)

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Glycolysis may briefly enhance energy production and offer partial protective effects in the setting of AKI, but its prolonged activation has been linked to adverse renal outcomes

Importantly, the VECAD IGF- 1R KD model recapitulates key features of early microvascular aging prior to the onset of overt muscle atrophy, making it a useful experimental system for studying pre-sarcopenia and identifying early vascular biomarkers of functional decline