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MEK1/2, Mitogen-Activated Protein Kinase Kinases 1/2

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CB dilutions were prepared in RPMI 1640 medium supplemented with 20% heat-inactivated fetal bovine serum (Gibco ) and Neomycin stock solution of 10,000 IU/ml (Sigma-Aldrich ) within 24 h before initiation of the experiment and stored at 4C

Grant support for this research comes from American Cancer Society MRSG-14-019-01-CDD (J.M.W), Postdoctoral Fellowship grant NIH/NCI F32CA247466 (A.V), American Cancer Society 134170-MBG-19-174-01-MBG (J.M.W.), NIH/NCI R37CA227865-01A1 (J.M.W), the Case Comprehensive Cancer Center GI SPORE 5P50CA150964-08 (J.M.W), and University Hospitals research start-up package (J.M.W.) We are grateful for additional support that contributed to this work from the John and Peggy Garson Family research fund, The Jerome A