FOXO4-DRI Safety and Side Effects: What the Evidence Shows (2026) In the published mouse studies, FOXO4-DRI caused no reported side effects: treated animals kept their weight, blood counts, and organ markers while senescent cells were cleared, and the peptide spared healthy cells in culture
In obesity, excessive fat accumulation leads to oxidative stress due to increased production of ROS in adipose tissue (Xia et al., 2022)
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