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This is possible because these medications act through different mechanisms

10.1002/mnfr.201400863 5 AtwellL

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No differences in 5-HT2A receptors in mid-life depression or LLD, lower 5HT2A receptors in mid-life depression in orbital-frontal cortex, and higher 5-HT2A receptors have been reported [109,110,111,112]

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