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Starting retatrutide at full maintenance doses after being on high-dose tirzepatide can lead to excessive GI side effects because of the additional glucagon receptor stimulation

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During the luteal phase, particularly 5-7 days before menstruation, antihistamines like loratadine and famotidine can be effective in managing the histamine reaction that contributes to skin irritation and rashes

(2023) 7:e0129