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Key considerations from available evidence: No direct hormonal mechanism linking tirzepatide to menstrual disruption has been identified Metabolic improvements (reduced insulin resistance, decreased androgens) may benefit women with PCOS The magnitude and rapidity of weight loss correlate with likelihood of temporary menstrual changes Long-term data on reproductive outcomes remain limited Healthcare providers should counsel women of reproductive age about potential menstrual changes when initiating tirzepatide

Baker LD, Espeland MA, Whitmer RA, et al

10.1073/pnas.0912437107 [DOI] [PMC free article] [PubMed] [Google Scholar] Benkhoucha M., Senoner I., Lalive P

Laboratory findings suggest support for mucosal integrity, reduced lesion severity, and improved epithelial healing through angiogenesis and inflammation modulation