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Randomized, placebo-controlled, pilot clinical study evaluating acute Niagen+ IV and NAD+ IV in healthy adults

The analysis of bone tissue morphology revealed that there were no alterations in the rate of bone formation or in the levels of calcitonin or sclerostin in these mice

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Lei S, Huang B (2022) Metabolic regulation of -Ketoglutarate associated with heat tolerance in perennial ryegrass

Therefore, the main renal concern is not proven direct tubular toxicity from alkaline or electrolyzed water itself, but the possibility that chronic or excessive intake of high-pH or mineral-rich water may worsen alkali load, electrolyte imbalance, fluid status, or acid base interpretation in susceptible patients