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The mechanism involves reshaping the gut microbiota (e.g., promoting Bifidobacteria growth), restoring key neurotransmitter (e.g., serotonin) balance, reducing inflammatory cytokine (e.g., TNF- ) levels, and promoting hippocampal neurogenesis

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For instance, an analysis of FAERS data (2014-2021) identified significant associations with interstitial lung disease (ILD) and pneumonitis, noting that 75.40% of events occurred within the first three months of treatment ( According to the latest raw statistics and our preliminary calculations from the FDA FAERS public dashboard ( In this context, a re-examination of the epidemiological features, temporal patterns, and clinical outcome differences of adverse events associated with PD-1/PD-L1 inhibitors is needed

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