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When enough electrons are lost without prompt replacement, this process of oxidation eventually results in cellular, and ultimately tissue, damage

HUBERMAN: So again, you want to avoid food in the hour and a half, probably two hours before taking them, and certainly in the half hour or longer after, which is why most people take them right before going to sleep, and add or augment that big growth hormone pulse that occurs in the early part of the night

Redox Signal 20 (4), 545556

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