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doi: 10.1038/s41392-025-02167-1 3 SaitoAIshikawaSYangKSawaAIshizukaK

The information below reports what is documented across pharmaceutical references, USP standards, and community discussions

Genetic Factors: HLA Genes : Variations in the human leukocyte antigen (HLA) genes, particularly HLA-DR3 and HLA-B8, have been associated with an increased risk of Graves disease

However, in aldehyde dehydrogenase 2 knockout (ALDH2 / ) mice (ALDH2an enzyme critical for protecting the heart against oxidative damage), no cardioprotective effects of ALA were observed