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Mech Ageing Dev 2000;120:1419

Mitochondrial dysfunction Imbalance of oxidation and antioxidation Mitochondrial ROS produced through the respiratory chain is the major source of ROS (Fig

[15] [16] Tests may include full blood count, serum B12 levels, anti-intrinsic factor antibodies (to diagnose pernicious anaemia), and sometimes methylmalonic acid or homocysteine levels when the diagnosis is uncertain

Application of D-retro-inverso (DRI) peptidomimetic chemistry to a FOXO4-derived interaction domain produced a 46-amino acid protease-resistant construct that has become a primary research tool in cellular senescence biology

2014;76:610e627